中山大学肿瘤防治中心 胃外科
胃癌的外科及综合治疗,尤其腹腔镜微创和保胃功能手术。
袁庶强,男,医学博士,副主任医师,硕士研究生导师,青年临床医学科学家。福建上杭人。2005、2008、2011年分别获中山大学临床医学学士、肿瘤学硕士、外科博士学位,2009-2011年往世界排名第一的美国MD Anderson肿瘤中心访问学习。从事腹部肿瘤外科的临床工作及基础研究十多年,擅长胃肠胰肿瘤的手术治疗,尤其是腹腔镜微创及保胃功能手术,熟悉辅助及新辅助放/化疗等多种治疗手段相结合的多学科综合治疗。主要科研方向:多药耐药逆转机制和肿瘤细胞能量代谢。主持国家自然科学基金等两项课题,共发表第一作者/通讯作者SCI论著30多篇。 社会任职 广东省精准医学应用学会胃肠肿瘤分会副主任委员 广东省抗癌协会胃癌专业委员会青年委员 广东省医学会胃肠外科学分会委员 广东省临床医学学会微创外科专业委员会委员 广东省医师协会微创外科分会委员 广东省医学教育协会普通外科学专业委员会委员 广东省医师协会肿瘤外科医师分会委员 中国研究型医院学会腹膜后与盆底疾病专业委员会委员 美国癌症研究协会(AACR)会员 美国临床肿瘤学会(ASCO)会员 获奖荣誉 “精术中国—手术视频演示大赛”,南中国区冠军,全腹腔镜根治性全胃切除术(2020) “叶任高-李幼姬”夫妇临床医学专业,优秀中青年教师奖(2019) 中山大学肿瘤医院首届微创视频大赛,三等奖,腹腔镜胃癌根治脾门淋巴结清扫术(2017) 中国医师协会中青年医师视频大赛,全国季军,全腹腔镜胃癌根治术(2016) 中山大学肿瘤医院青年临床医学科学家(2015) AME胃肠外科疑难病例英文挑战赛,南中国赛区冠军(2014) 中山大学肿瘤医院英文授课比赛,三等奖(2013) 科研成果 一.主持课题 [1]. 中山大学肿瘤防治中心临床医学科学家培养项目,07030301,靶向糖酵解代谢酶GAPDH逆转胃肠肿瘤细胞多药耐药性的作用和机制研究,2015/01-2019/12,50万元 [2]. 国家自然科学基金青年科学基金项目,81302144,新型糖酵解抑制剂3-BrOP逆转胃肠肿瘤细胞多药耐药性的作用及其机制,2014/01-2016/12,23万元 二.代表论著 1. Chen XJ, Yuan SQ, Duan JL, Chen YM, Chen S, Wang Y, Li YF: The Value of PD-L1 Expression in Predicting the Efficacy of Anti-PD-1 or Anti-PD-L1 Therapy in Patients with Cancer: A Systematic Review and Meta-Analysis. Dis Markers 2020, 2020:6717912. 2. Liu Z, Zhao Q, Zuo ZX, Yuan SQ, Yu K, Zhang Q, Zhang X, Sheng H, Ju HQ, Cheng H et al: Systematic Analysis of the Aberrances and Functional Implications of Ferroptosis in Cancer. iScience 2020, 23(7):101302. 3. Nie RC, Yuan SQ, Wang Y, Zou XB, Chen S, Li SM, Duan JL, Zhou J, Chen GM, Luo TQ et al: Surrogate endpoints for overall survival in anti-programmed death-1 and anti-programmed death ligand 1 trials of advanced melanoma. Ther Adv Med Oncol 2020, 12:1758835920929583. 4. Chen GM, Yuan SQ, Nie RC, Luo TQ, Jiang KM, Liang CC, Li YF, Zhang DY, Yu JH, Hou F et al: Surgical Outcome and Long-Term Survival of Conversion Surgery for Advanced Gastric Cancer. Ann Surg Oncol 2020. 5. Nie RC, Zou XB, Yuan SQ, Chen YB, Chen S, Chen YM, Chen GM, Chen XJ, Luo TQ, Li SM et al: Disease-free survival as a surrogate endpoint for overall survival in adjuvant trials of pancreatic cancer: a meta-analysis of 20 randomized controlled trials. BMC Cancer 2020, 20(1):421. 6. Xu LP, Qiu HB, Yuan SQ, Chen YM, Zhou ZW, Chen YB: Downregulation of PSCA promotes gastric cancer proliferation and is related to poor prognosis. J Cancer 2020, 11(9):2708-2715. 7. Nie RC, Yuan SQ, Wang Y, Chen YB, Cai YY, Chen S, Li SM, Zhou J, Chen GM, Luo TQ et al: Robust immunoscore model to predict the response to anti-PD1 therapy in melanoma. Aging (Albany NY) 2019, 11(23):11576-11590. 8. Nie R, Yuan S, Li Y, Chen S, Li S, Yang L, Yang L, Chen Y, Zhou Z: Risk-stratification model to select conversion surgery for advanced gastric cancer patients. Chin J Cancer Res 2019, 31(1):178-187. 9. Nie RC, Yuan SQ, Li YF, Chen S, Chen YM, Chen XJ, Chen GM, Zhou ZW, Chen YB: Additional gastrectomy in early-stage gastric cancer after non-curative endoscopic resection: a meta-analysis. Gastroenterol Rep (Oxf) 2019, 7(2):91-97. 10. Zhu BY, Yuan SQ, Nie RC, Li SM, Yang LR, Duan JL, Chen YB, Zhang XS: Prognostic Factors and Recurrence Patterns in T4 Gastric Cancer Patients after Curative Resection. J Cancer 2019, 10(5):1181-1188. 11. Li YF, Nie RC, Wu T, Li SM, Chen S, Wang W, Chen XJ, Chen GM, Chen YB, Zhou ZW et al: Prognostic Value of the Nutritional Risk Screening 2002 Scale in Metastatic Gastric Cancer: A Large-Scale Cohort Study. J Cancer 2019, 10(1):112-119. 12. Nie RC, Chen FP, Yuan SQ, Luo YS, Chen S, Chen YM, Chen XJ, Chen YB, Li YF, Zhou ZW: Evaluation of objective response, disease control and progression-free survival as surrogate end-points for overall survival in anti-programmed death-1 and anti-programmed death ligand 1 trials. Eur J Cancer 2019, 106:1-11. 13. Ma MZ, Yuan SQ, Chen YM, Zhou ZW: Preoperative apolipoprotein B/apolipoprotein A1 ratio: a novel prognostic factor for gastric cancer. Onco Targets Ther 2018, 11:2169-2176. 14. Nie RC, Yuan SQ, Chen S, Yan SM, Chen YM, Chen XJ, Chen GM, Zhou ZW, Chen YB, Li YF: Bursectomy for advanced gastric cancer: an update meta-analysis. World J Surg Oncol 2018, 16(1):66. 15. Yuan SQ, Nie RC, Chen YM, Qiu HB, Li XP, Chen XJ, Xu LP, Yang LF, Sun XW, Li YF et al: Glasgow Prognostic Score is superior to ECOG PS as a prognostic factor in patients with gastric cancer with peritoneal seeding. Oncol Lett 2018, 15(4):4193-4200. 16. Yuan SQ, Wu WJ, Qiu MZ, Wang ZX, Yang LP, Jin Y, Yun JP, Gao YH, Li YH, Zhou ZW et al: Development and Validation of a Nomogram to Predict the Benefit of Adjuvant Radiotherapy for Patients with Resected Gastric Cancer. J Cancer 2017, 8(17):3498-3505. 17. Nie RC, Yuan SQ, Li YF, Chen YM, Chen XJ, Zhu BY, Xu LP, Zhou ZW, Chen S, Chen YB: Clinicopathological Characteristics and Prognostic Value of Signet Ring Cells in Gastric Carcinoma: A Meta-Analysis. J Cancer 2017, 8(17):3396-3404. 18. Seeruttun SR, Yuan S, Qiu H, Huang Y, Li Y, Liang Y, Guan Y, Zhan Y, Li W, Chen Y et al: A comprehensive analysis comparing the eighth AJCC gastric cancer pathological classification to the seventh, sixth, and fifth editions. Cancer Med 2017, 6(12):2804-2813. 19. Yuan SQ, Nie RC, Chen S, Chen XJ, Chen YM, Xu LP, Yang LF, Zhou ZW, Peng JS, Chen YB: Selective Gastric Cancer Patients with Peritoneal Seeding Benefit from Gastrectomy after Palliative Chemotherapy: A Propensity Score Matching Analysis. J Cancer 2017, 8(12):2231-2237. 20. Yuan SQ, Chen YT, Huang ZP: Equipping the 8th Edition American Joint Committee on Cancer Staging for Gastric Cancer with the 15-Node Minimum: a Population-Based Study Using Recursive Partitioning Analysis. J Gastrointest Surg 2017, 21(10):1591-1598. 21. Nie RC, Yuan SQ, Chen XJ, Chen S, Xu LP, Chen YM, Zhu BY, Sun XW, Zhou ZW, Chen YB: Endoscopic ultrasonography compared with multidetector computed tomography for the preoperative staging of gastric cancer: a meta-analysis. World J Surg Oncol 2017, 15(1):113. 22. Nie R, Yuan S, Chen S, Chen X, Chen Y, Zhu B, Qiu H, Zhou Z, Peng J, Chen Y: Prognostic nutritional index is an independent prognostic factor for gastric cancer patients with peritoneal dissemination. Chin J Cancer Res 2016, 28(6):570-578. 23. Nie RC, Chen S, Yuan SQ, Chen XJ, Chen YM, Zhu BY, Qiu HB, Peng JS, Chen YB: Significant Role of Palliative Gastrectomy in Selective Gastric Cancer Patients with Peritoneal Dissemination: A Propensity Score Matching Analysis. Ann Surg Oncol 2016, 23(12):3956-3963. 24. Yuan S, Lu Y, Yang J, Chen G, Kim S, Feng L, Ogasawara M, Hammoudi N, Lu W, Zhang H et al: Metabolic activation of mitochondria in glioma stem cells promotes cancer development through a reactive oxygen species-mediated mechanism. Stem Cell Res Ther 2015, 6:198. 25. Yuan S, Wang F, Chen G, Zhang H, Feng L, Wang L, Colman H, Keating MJ, Li X, Xu RH et al: Effective elimination of cancer stem cells by a novel drug combination strategy. Stem Cells 2013, 31(1):23-34. 26. Wang F, Yuan S, Teng KY, Garcia-Prieto C, Luo HY, Zeng MS, Rao HL, Xia Y, Jiang WQ, Huang HQ et al: High hepatitis B virus infection in B-cell lymphoma tissue and its potential clinical relevance. Eur J Cancer Prev 2012, 21(3):261-267. 27. Tang Z, Yuan S, Hu Y, Zhang H, Wu W, Zeng Z, Yang J, Yun J, Xu R, Huang P: Over-expression of GAPDH in human colorectal carcinoma as a preferred target of 3-bromopyruvate propyl ester. J Bioenerg Biomembr 2012, 44(1):117-125. 28. Yuan SQ, Zhou ZW, Liang YJ, Fu LW, Chen G, Qiu HB, Zhang LY: [Correlation of chemosensitivity tested using histoculture drug response assay to expression of multidrug resistance genes and proteins in colorectal cancer tissues]. Ai Zheng 2009, 28(9):932-938. 29. Yuan SQ, Zhou ZW, Liang YJ, Fu LW, Chen G, Keshari RP, Zhang LY: [Correlation of chemosensitivity measured by histoculture drug response assay to expression of multidrug resistance genes and proteins in gastric cancer]. Ai Zheng 2009, 28(4):337-343. 30. Yuan SQ, Zhou ZW, Wan DS, Chen G, Lu ZH, Wang GQ, Pan ZZ: The role of half-life of carcinoembryonic antigen (CEA) in prognosis prediction of colorectal cancer patients with preoperatively elevated CEA. Ai Zheng 2008, 27(6):612-617. 进修经历 2009年4月-2011年4月美国MD Anderson肿瘤中心 工作经历 2018年1月-至今中山大学附属肿瘤医院副主任医师 2014年1月-2017年12月中山大学附属肿瘤医院主治医师 2011年7月-2013年12月中山大学附属肿瘤医院住院医师 教育经历 博士中山大学附属第六医院外科学 硕士中山大学附属肿瘤医院肿瘤学 本科中山大学中山医学院临床医学
胃癌的外科及综合治疗,尤其腹腔镜微创和保胃功能手术。
袁庶强,男,医学博士,副主任医师,硕士研究生导师,青年临床医学科学家。福建上杭人。2005、2008、2011年分别获中山大学临床医学学士、肿瘤学硕士、外科博士学位,2009-2011年往世界排名第一的美国MD Anderson肿瘤中心访问学习。从事腹部肿瘤外科的临床工作及基础研究十多年,擅长胃肠胰肿瘤的手术治疗,尤其是腹腔镜微创及保胃功能手术,熟悉辅助及新辅助放/化疗等多种治疗手段相结合的多学科综合治疗。主要科研方向:多药耐药逆转机制和肿瘤细胞能量代谢。主持国家自然科学基金等两项课题,共发表第一作者/通讯作者SCI论著30多篇。 社会任职 广东省精准医学应用学会胃肠肿瘤分会副主任委员 广东省抗癌协会胃癌专业委员会青年委员 广东省医学会胃肠外科学分会委员 广东省临床医学学会微创外科专业委员会委员 广东省医师协会微创外科分会委员 广东省医学教育协会普通外科学专业委员会委员 广东省医师协会肿瘤外科医师分会委员 中国研究型医院学会腹膜后与盆底疾病专业委员会委员 美国癌症研究协会(AACR)会员 美国临床肿瘤学会(ASCO)会员 获奖荣誉 “精术中国—手术视频演示大赛”,南中国区冠军,全腹腔镜根治性全胃切除术(2020) “叶任高-李幼姬”夫妇临床医学专业,优秀中青年教师奖(2019) 中山大学肿瘤医院首届微创视频大赛,三等奖,腹腔镜胃癌根治脾门淋巴结清扫术(2017) 中国医师协会中青年医师视频大赛,全国季军,全腹腔镜胃癌根治术(2016) 中山大学肿瘤医院青年临床医学科学家(2015) AME胃肠外科疑难病例英文挑战赛,南中国赛区冠军(2014) 中山大学肿瘤医院英文授课比赛,三等奖(2013) 科研成果 一.主持课题 [1]. 中山大学肿瘤防治中心临床医学科学家培养项目,07030301,靶向糖酵解代谢酶GAPDH逆转胃肠肿瘤细胞多药耐药性的作用和机制研究,2015/01-2019/12,50万元 [2]. 国家自然科学基金青年科学基金项目,81302144,新型糖酵解抑制剂3-BrOP逆转胃肠肿瘤细胞多药耐药性的作用及其机制,2014/01-2016/12,23万元 二.代表论著 1. Chen XJ, Yuan SQ, Duan JL, Chen YM, Chen S, Wang Y, Li YF: The Value of PD-L1 Expression in Predicting the Efficacy of Anti-PD-1 or Anti-PD-L1 Therapy in Patients with Cancer: A Systematic Review and Meta-Analysis. Dis Markers 2020, 2020:6717912. 2. Liu Z, Zhao Q, Zuo ZX, Yuan SQ, Yu K, Zhang Q, Zhang X, Sheng H, Ju HQ, Cheng H et al: Systematic Analysis of the Aberrances and Functional Implications of Ferroptosis in Cancer. iScience 2020, 23(7):101302. 3. Nie RC, Yuan SQ, Wang Y, Zou XB, Chen S, Li SM, Duan JL, Zhou J, Chen GM, Luo TQ et al: Surrogate endpoints for overall survival in anti-programmed death-1 and anti-programmed death ligand 1 trials of advanced melanoma. Ther Adv Med Oncol 2020, 12:1758835920929583. 4. Chen GM, Yuan SQ, Nie RC, Luo TQ, Jiang KM, Liang CC, Li YF, Zhang DY, Yu JH, Hou F et al: Surgical Outcome and Long-Term Survival of Conversion Surgery for Advanced Gastric Cancer. Ann Surg Oncol 2020. 5. Nie RC, Zou XB, Yuan SQ, Chen YB, Chen S, Chen YM, Chen GM, Chen XJ, Luo TQ, Li SM et al: Disease-free survival as a surrogate endpoint for overall survival in adjuvant trials of pancreatic cancer: a meta-analysis of 20 randomized controlled trials. BMC Cancer 2020, 20(1):421. 6. Xu LP, Qiu HB, Yuan SQ, Chen YM, Zhou ZW, Chen YB: Downregulation of PSCA promotes gastric cancer proliferation and is related to poor prognosis. J Cancer 2020, 11(9):2708-2715. 7. Nie RC, Yuan SQ, Wang Y, Chen YB, Cai YY, Chen S, Li SM, Zhou J, Chen GM, Luo TQ et al: Robust immunoscore model to predict the response to anti-PD1 therapy in melanoma. Aging (Albany NY) 2019, 11(23):11576-11590. 8. Nie R, Yuan S, Li Y, Chen S, Li S, Yang L, Yang L, Chen Y, Zhou Z: Risk-stratification model to select conversion surgery for advanced gastric cancer patients. Chin J Cancer Res 2019, 31(1):178-187. 9. Nie RC, Yuan SQ, Li YF, Chen S, Chen YM, Chen XJ, Chen GM, Zhou ZW, Chen YB: Additional gastrectomy in early-stage gastric cancer after non-curative endoscopic resection: a meta-analysis. Gastroenterol Rep (Oxf) 2019, 7(2):91-97. 10. Zhu BY, Yuan SQ, Nie RC, Li SM, Yang LR, Duan JL, Chen YB, Zhang XS: Prognostic Factors and Recurrence Patterns in T4 Gastric Cancer Patients after Curative Resection. J Cancer 2019, 10(5):1181-1188. 11. Li YF, Nie RC, Wu T, Li SM, Chen S, Wang W, Chen XJ, Chen GM, Chen YB, Zhou ZW et al: Prognostic Value of the Nutritional Risk Screening 2002 Scale in Metastatic Gastric Cancer: A Large-Scale Cohort Study. J Cancer 2019, 10(1):112-119. 12. Nie RC, Chen FP, Yuan SQ, Luo YS, Chen S, Chen YM, Chen XJ, Chen YB, Li YF, Zhou ZW: Evaluation of objective response, disease control and progression-free survival as surrogate end-points for overall survival in anti-programmed death-1 and anti-programmed death ligand 1 trials. Eur J Cancer 2019, 106:1-11. 13. Ma MZ, Yuan SQ, Chen YM, Zhou ZW: Preoperative apolipoprotein B/apolipoprotein A1 ratio: a novel prognostic factor for gastric cancer. Onco Targets Ther 2018, 11:2169-2176. 14. Nie RC, Yuan SQ, Chen S, Yan SM, Chen YM, Chen XJ, Chen GM, Zhou ZW, Chen YB, Li YF: Bursectomy for advanced gastric cancer: an update meta-analysis. World J Surg Oncol 2018, 16(1):66. 15. Yuan SQ, Nie RC, Chen YM, Qiu HB, Li XP, Chen XJ, Xu LP, Yang LF, Sun XW, Li YF et al: Glasgow Prognostic Score is superior to ECOG PS as a prognostic factor in patients with gastric cancer with peritoneal seeding. Oncol Lett 2018, 15(4):4193-4200. 16. Yuan SQ, Wu WJ, Qiu MZ, Wang ZX, Yang LP, Jin Y, Yun JP, Gao YH, Li YH, Zhou ZW et al: Development and Validation of a Nomogram to Predict the Benefit of Adjuvant Radiotherapy for Patients with Resected Gastric Cancer. J Cancer 2017, 8(17):3498-3505. 17. Nie RC, Yuan SQ, Li YF, Chen YM, Chen XJ, Zhu BY, Xu LP, Zhou ZW, Chen S, Chen YB: Clinicopathological Characteristics and Prognostic Value of Signet Ring Cells in Gastric Carcinoma: A Meta-Analysis. J Cancer 2017, 8(17):3396-3404. 18. Seeruttun SR, Yuan S, Qiu H, Huang Y, Li Y, Liang Y, Guan Y, Zhan Y, Li W, Chen Y et al: A comprehensive analysis comparing the eighth AJCC gastric cancer pathological classification to the seventh, sixth, and fifth editions. Cancer Med 2017, 6(12):2804-2813. 19. Yuan SQ, Nie RC, Chen S, Chen XJ, Chen YM, Xu LP, Yang LF, Zhou ZW, Peng JS, Chen YB: Selective Gastric Cancer Patients with Peritoneal Seeding Benefit from Gastrectomy after Palliative Chemotherapy: A Propensity Score Matching Analysis. J Cancer 2017, 8(12):2231-2237. 20. Yuan SQ, Chen YT, Huang ZP: Equipping the 8th Edition American Joint Committee on Cancer Staging for Gastric Cancer with the 15-Node Minimum: a Population-Based Study Using Recursive Partitioning Analysis. J Gastrointest Surg 2017, 21(10):1591-1598. 21. Nie RC, Yuan SQ, Chen XJ, Chen S, Xu LP, Chen YM, Zhu BY, Sun XW, Zhou ZW, Chen YB: Endoscopic ultrasonography compared with multidetector computed tomography for the preoperative staging of gastric cancer: a meta-analysis. World J Surg Oncol 2017, 15(1):113. 22. Nie R, Yuan S, Chen S, Chen X, Chen Y, Zhu B, Qiu H, Zhou Z, Peng J, Chen Y: Prognostic nutritional index is an independent prognostic factor for gastric cancer patients with peritoneal dissemination. Chin J Cancer Res 2016, 28(6):570-578. 23. Nie RC, Chen S, Yuan SQ, Chen XJ, Chen YM, Zhu BY, Qiu HB, Peng JS, Chen YB: Significant Role of Palliative Gastrectomy in Selective Gastric Cancer Patients with Peritoneal Dissemination: A Propensity Score Matching Analysis. Ann Surg Oncol 2016, 23(12):3956-3963. 24. Yuan S, Lu Y, Yang J, Chen G, Kim S, Feng L, Ogasawara M, Hammoudi N, Lu W, Zhang H et al: Metabolic activation of mitochondria in glioma stem cells promotes cancer development through a reactive oxygen species-mediated mechanism. Stem Cell Res Ther 2015, 6:198. 25. Yuan S, Wang F, Chen G, Zhang H, Feng L, Wang L, Colman H, Keating MJ, Li X, Xu RH et al: Effective elimination of cancer stem cells by a novel drug combination strategy. Stem Cells 2013, 31(1):23-34. 26. Wang F, Yuan S, Teng KY, Garcia-Prieto C, Luo HY, Zeng MS, Rao HL, Xia Y, Jiang WQ, Huang HQ et al: High hepatitis B virus infection in B-cell lymphoma tissue and its potential clinical relevance. Eur J Cancer Prev 2012, 21(3):261-267. 27. Tang Z, Yuan S, Hu Y, Zhang H, Wu W, Zeng Z, Yang J, Yun J, Xu R, Huang P: Over-expression of GAPDH in human colorectal carcinoma as a preferred target of 3-bromopyruvate propyl ester. J Bioenerg Biomembr 2012, 44(1):117-125. 28. Yuan SQ, Zhou ZW, Liang YJ, Fu LW, Chen G, Qiu HB, Zhang LY: [Correlation of chemosensitivity tested using histoculture drug response assay to expression of multidrug resistance genes and proteins in colorectal cancer tissues]. Ai Zheng 2009, 28(9):932-938. 29. Yuan SQ, Zhou ZW, Liang YJ, Fu LW, Chen G, Keshari RP, Zhang LY: [Correlation of chemosensitivity measured by histoculture drug response assay to expression of multidrug resistance genes and proteins in gastric cancer]. Ai Zheng 2009, 28(4):337-343. 30. Yuan SQ, Zhou ZW, Wan DS, Chen G, Lu ZH, Wang GQ, Pan ZZ: The role of half-life of carcinoembryonic antigen (CEA) in prognosis prediction of colorectal cancer patients with preoperatively elevated CEA. Ai Zheng 2008, 27(6):612-617. 进修经历 2009年4月-2011年4月美国MD Anderson肿瘤中心 工作经历 2018年1月-至今中山大学附属肿瘤医院副主任医师 2014年1月-2017年12月中山大学附属肿瘤医院主治医师 2011年7月-2013年12月中山大学附属肿瘤医院住院医师 教育经历 博士中山大学附属第六医院外科学 硕士中山大学附属肿瘤医院肿瘤学 本科中山大学中山医学院临床医学
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